PhotoLab clearly reports when it can’t load an image file because the image type isn’t supported. That shouldn’t produce a “loading error in block load” fault. My guess is that this is a problem actually reading the file in its stored location. It could be a corrupt file or a data transmission problem. You should probably investigate this through technical support (support.dxo.com) so that you don’t have to divulge much about your file system here. But can you give us more details about this DNG file and where it’s located?