I stumbled upon this thread by accident. It is a thread that was started long, and I have to admit first that I didn’t read all entries.
I’ve used Vuescan many years for slide scans and B&W negative scans, the program is excellent. But the RAW file generated by Vuescan in .dng format is very different from the RAW .dng files from digital cameras. They are mainly used to re-process them later (in Vuescan), if desired, without the need to scan again.
So I’m not surprised that they can’t be opened in PL. I know they can be opened in ACR, but I am aware of several other RAW converters that can’t handle Vuescans .dng’s.
Of course DP and DP-XD are useless, because they are camera-specific. The best way to handle noise in film scans is, in my experience, the use of a dedicated application like Neat Image. N.I. will analyze a homogeneous part of the image, make a frequency-dependent noise profile and there are many parameters that you can tune to eliminate the noise to taste.
This is the above image, processed with more or less default parameters, in Neat Image:
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