Pure Raw 4 will not update with slider changes

When I open a CR3 file in PR4, the program denoises and applies sharpening, but will not respond to any changes I make after that. This is not isolated to the preview; the program shows different levels of sharpness as I change them, but will not apply the settings.

I have restarted the program, cleared the lightbox and restarted the computer to no avail.

Any advice is greatly appreciated.

Update: it seems the sliders respond to some images but not others. Macro shots of insects tend to get ignored, but subjects with fur or of flowers get updated with changes. I’m having difficulty understanding why the program would act this way…