Not having the time to produce such a list, I asked HAL 9000 to do so (this is also an excellent opportunity to see if HAL made mistakes in its research, should one accept that challenge).
“JUST A MOMENT… JUST A MOMENT…
When editing a JPEG or TIFF in DxO PhotoLab instead of a RAW file, several key tools and underlying algorithms are disabled because they specifically require unprocessed sensor data.
Here is the list of features that are unavailable or restricted when processing JPEGs:
1. AI Noise Reduction: The advanced DeepPRIME, DeepPRIME XD, and DeepPRIME XD2 denoising algorithms are strictly for RAW files. For JPEGs, you are limited to the legacy High Quality (HQ) noise reduction.
2. White Balance (Local Adjustments): As you noted, the White Balance slider (Color Temperature and Tint) is completely disabled within all Local Adjustments (Control Points, Control Lines, Auto Masks, etc.) for JPEGs.
3. White Balance (Global): While the global White Balance tool is active for JPEGs, it loses its absolute controls. You cannot enter absolute Kelvin temperature values, nor can you use camera-specific lighting presets (Daylight, Tungsten, Cloudy). You are restricted to a relative “Cold to Warm” slider.
4. Moiré Reduction: The Moiré tool, located in the Detail palette, is entirely disabled for JPEGs. It is a RAW-only feature designed to eliminate pattern artifacts during the demosaicing process.
5. Camera Body Color Rendering: In the Color Rendering palette, the ability to apply specific Camera Body profiles (e.g., applying Leica or Canon color science to a Nikon image) is restricted to RAW files. JPEGs are limited to applying FilmPack emulations or sticking to their baked-in color space.
6. Dead Pixel Correction: DxO PhotoLab automatically identifies and removes hot or dead sensor pixels in the background, but this automatic correction only occurs during RAW demosaicing.
7. Highlight Reconstruction (Exposure): While the Exposure Compensation and Smart Lighting tools remain active, the fundamental ability to recover blown highlight detail (using sensor data that exceeds the visible white point) is impossible on an 8-bit JPEG. JPEGs will simply turn clipped white areas into flat gray when the exposure is reduced.”