Issue with PS plugin

I am noticing that sometimes maybe an hour into an editing session when I have perhaps used Nik and other plugins multiple times on different images, when I run say Color efex in PS and then stack multiple effects, when I process that and return to PS, the layer created by Color Efex is just black. I have checked my resource monitor and I am not running out of RAM on my Win 10 PC (I have 32GB RAM and 6GB VRAM), and I am not running out of HD space. Anyone else ever see this? Seems to happen particularly when stacking multiple effects in Color Efex. Using Win 11 and the latest version of Photoshop (not beta)