This is an important point. If you add, say, DeepPRIME noise reduction to the image, you will get the equivalent amount of the High Quality noise reduction shown in the viewer while editing. I find this is useful in at least masking the worst of the effects of strong noise.
When it comes to “creative sharpening” I am not sure what you’re trying to achieve, but for my purposes, I love a tack sharp image and in all the many thousands I have processed with PhotoLab, I have never once used the Unsharp Mask. The lens sharpness can already way over sharpen things if you push it up beyond the default. I do almost always use a setting >0 on lens sharpness, to really pick out panel lines or feather detail, but if I have a very fine and dense detail, such as grasses, I usually have to back it off or it looks really obvious that it has been applied.
My favourite subject matters are aircraft and birds. I find +0.25 works well on most of these shots and have this baked into my starting presets. I usually only discover I forgot to back it off when I look at a final exported shot, and this is another important point — the effect of any sharpness tool will differ with output scaling, too. What looks fine at 100% may end up looking terrible when scaled down.