Just wanted to add something. DxO deals with difficult images better. I was in Tokyo a long time ago (it seems) and I once had forgotten to switch on the long time exposure denoise feature on my Lumix G9 
So in the end images with lots of sensor noise and hot pixels. Topaz leaves something to be desired since a lot of noise is left after the AI treatment. I think with DxO you have more options to deal with such situations better.
Original image
Topaz
DxOPrime
