A old thread but it covers the theory behind the sliders. At least i tried to reveal that.
i am lazy and have PRIME always on, with m43 default would be ok.
i suspect that if you test on different settings i advise to use Dfine2 as a kind of Tiff after noise reduction denoiser to see how much dfine2 is redoing again.
i found Dfine2 and essential HQ or prime default and Dfine2 almost the same as 70 on prime.
(night shots on 6400iso and 3200iso was my test images)
Its mostly personal perception of what you find too smutched, polished out detail, or to noisy.
sharpening/denoise is always a kind of “feel” of end goal. a grainy black and white high contrast and detail but noisy or a “plastic” colorfull clean image. and all in between.
Maybe its a idea to place some image here and we get a run with it trying to get the best you want. See which settings are popping up. 